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Due to the recent hot weather, the Appliance Service Plan call center is experiencing increased wait times for air conditioning repairs. We are sorry for the inconvenience. *This program is not regulated by the Michigan Public Service Commission and not available in all areas.
Due to the recent hot weather, the Appliance Service Plan call center is experiencing increased wait times for air conditioning repairs. We are sorry for the inconvenience. *This program is not regulated by the Michigan Public Service Commission and not available in all areas.
There is a severe weather alert in your area that could cause outages.
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This website translates English to other languages using an automated tool. We cannot guarantee the accuracy of the translated text.
When a patient is in the hospital, he or she often needs to be given medicines or fluids or have blood. Sometimes this is done through a central line or catheter. A central line is a tube that is put into a large vein, usually in the neck, chest, arm or groin. The line may be left in place for several weeks. The risk of infection increases with the increased duration of time a central line is in place.
If bacteria or other germs get into a central line, they can enter the bloodstream and cause an infection. Signs of such an infection may include fevers and chills. Sometimes, the area around where the tube has been inserted into the vein becomes red or sore.
These types of infections are serious. They often can be treated successfully with antibiotics and removal of the central line.
At Cedars-Sinai, many precautions are taken to prevent central line associated bloodstream infections, including:
As part of its commitment to improving the quality of care given to patients at Cedars-Sinai, the rate of central line infections is monitored carefully.
California hospitals are required to report these infections to the California Department of Public Health and the National Healthcare Safety Network, part of the Centers for Disease Control and Prevention (CDC). The California department is required to adjust the data for risk factors according to the federal network's protocols. The risk adjustment methodology uses national data to compare the actual number of infections to the expected number, based on the age and health of the surgery patients.
The chart below shows the rate of central line-linked bloodstream infections that occurred in patients in the Adult Intensive Care Units at Cedars-Sinai vs. the expected number.
What Is the Standardized Infection Ratio?
The standardized infection ratio is a summary measure used to track infections at a national, state or local level over time. The ratio compares the actual number of infections reported to what would be predicted, adjusting for risk factors that have been found to be significantly associated with differences in infection incidence. A lower number is better. Impact onStandardized Infection Ratios After 2015 Rebaselining
The National Healthcare Safety Network instituted the new 2015 baseline time period for the number predicted calculation. The data included in the 2015 baseline will serve as a new reference point for comparing progress. CDC expects that hospital standardized infection ratios will increase and shift closer to 1. This shift reflects nationwide improvement in infection prevention from the previous baseline time period.
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Therapies with inconsistent cardioprotective efficacy: Many of the cardioprotective therapies that have failed in the clinical setting did not show consistent and robust cardioprotection in the experimental setting. This can be attributed to methodological limitations of the pre-clinical studies including lack of randomization, non-blinded treatment allocation, non-blinded data analysis, lack of standardized animal AMI/HF models and acute IRI protocols, and the lack of rigor in statistical methods. Therefore, more rigorous testing of novel cardioprotective therapies in the experimental setting are required to ensure that only the most promising therapies are investigated in the clinical arena.
To address this, the aim of Working Group 4 (CONSORTIUM) of our EU-CARDIOPROTECTION COST Action will be to set up a European Cardioprotection Consortium (ECC) for multi-center experimental testing of new cardioprotective therapies in clinically relevant small/large animals, and for testing new cardioprotective therapies in proof-of-concept clinical studies in patients subjected to acute IRI including ST-segment elevation myocardial infarction (STEMI) and coronary artery bypass graft (CABG) patients.
Working Group 1: New Targets
The majority of the experimental studies investigating novel cardioprotective therapies have focused on targeting well-established signaling pathways/targets, many of which have not proven to be beneficial in the clinical setting. In some respects, this may have been because the therapy had not been optimized in terms of the experimental setting (dose, acute versus chronic administration and timing of therapy), and in this regard, there is an opportunity to optimize the treatment approach. In other cases, in which treatments have failed, novel therapeutic targets and strategies need to be discovered in order to improve the translation of cardioprotection from the laboratory to the clinical setting. These new cardioprotective strategies should focus on (a) discovering new therapeutic targets in novel cardioprotective pathways within the cardiomyocyte and (b) other components of acute IRI outside of the cardiomyocyte such as the microvasculature, inflammatory cells, and platelets. Potential novel targets for cardioprotection include i) inflammation targets such as macrophages/lymphocytes, RNA/DNA, and inflammasome; ii) novel mechanisms of cell death such as necroptosis and pyroptosis; iii) extracellular matrix; iv) fibroblasts; v) endothelial cells and vascular smooth muscle; vi) platelets and vii) novel mitochondrial targets(
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); and viii) novel insulin targets and zinc-transporters targets associated with sarcolemma, sarco(endo)plasmic reticulum and mitochondria in hyperglycemic, failing and aging heart (
Tuncay et al., 2017
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, rates are still expected to go up sometime this year, which is great news if you've been discouraged by the next-to-nothing interest rates banks pay on your savings. But if you have a
home equity line of credit
or a credit card with an interest rate tied to the rates set by the Federal Reserve, you may be looking at higher payments.
This news can make a big difference if you're on a tight budget, because your payments can go up later this year. If rates do go up, what will it mean to your monthly payments?
Click ahead for a look at which of your bills will go up when the central bank raises interest rates.
If you already have a low fixed-rate mortgage, you've got nothing to worry about (as long as you don't move and take out a new mortgage). But if you have a home equity line of credit or an adjustable-rate mortgage, you could see your rate -- and payments -- rise. But what will it actually cost you?
Let's say you have a $50,000 balance on a home equity loan that is currently on a 15-year repayment schedule. At a 4.5 percent interest rate, the monthly payment is $382.50. But at a 5.5 percent rate, it goes up to $408.54. And if the rate rises another percentage point to 6.5 percent, the payment goes up to $435.55. The difference on a mortgage with a bigger balance -- say $250,000 -- is even larger. (You can use this home affordability calculator to run the numbers for your own situation.)
Most credit card programs carry variable rates. That means that when interest rates in the economy begin to rise, credit card rates may adjust as well. While you probably won't see a drastic change immediately, it could well be a "frog in the boiling pot of water" situation; gradual rate increases don't feel so bad at first, but over time they make it difficult to pay off the debt (
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If you don't have a low rate already, consider consolidating debt with a low-interest credit card or personal loan. If you can't qualify due to credit problems, a credit counseling agency may be able to help you lock in lower rates and pay off your balances in five years or less.
Most auto loans carry fixed interest rates but a few have variable interest rates. Auto buyers probably don't need to worry too much about rising rates, Edmunds.com Chief Economist Lacey Plache told us back in January. "Auto makers can and (I expect) will subsidize lower auto loan rates so as not to scare off buyers and lose the strong sales momentum they are enjoying at present," she observes.
If you have a car loan at a decent rate, stick with it. If you will be shopping for a vehicle, shop carefully for the right car and the right auto loan before you walk into a dealership.
Whether rates will increase this month or later this year, the truth is your credit score will likely
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This is a perfect page. Thank you!
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Thanks, THIS PAGE HELP ME TO PREPARE A SPEACH ABOUT "FOLLOW UP "
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Posted by: NAASI | January 31, 2013 at 07:46 PM
Excellent! I hope you succeeded.
Lynn
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What about this sentence. Does useage of Follow up need a hyphen? To me it appears as a noun in this sentence, but (the) does not fit in front of it.
"This column should be listed as OK if no follow up error is determined"
Posted by: Glenna | June 26, 2013 at 06:37 AM
Hi, Glenna. Your "follow-up" is an adjective and needs a hyphen.
You can put "the" in front of it: "This column should be listed as OK if the follow-up error is determined."
Yes, "the" changes the meaning of your sentence, but it does work in that construction.
Lynn
Posted by: Lynn Gaertner-Johnston | June 27, 2013 at 10:34 PM
This is a good post, but it is not entirely accurate. For example, the subject of an email might be "Follow-up to our October meeting." Here, follow-up functions as a noun, but placing "the" in front of follow-up would be awkward ("The follow-up to our October meeting") and perhaps inaccurate. It is not the case, then, that "if you cannot insert the before follow up, you know the phrase is a verb."
Posted by: doug | October 02, 2013 at 01:24 PM
Hi, Doug. You may choose not to place "the" in front of your subject, but you could. It might be slightly awkward, but there's really nothing wrong with it. That's why you know the phrase needs a hyphen.
In contrast, if your subject were "Please Follow Up on Our October Meeting," "the" would make no sense before "follow up." That's how you know the hyphen would be wrong there.
Thanks for the interesting example.
Lynn
Posted by:
Lynn Gaertner-Johnston
|
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